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San Francisco 49ers vs Los Angeles Rams 9/17/2023 Analysis, Picks and Predictions

San Francisco 49ers vs Los Angeles Rams 9/17/2023 – Get ready for a thrilling matchup as the Los Angeles Rams take on the San Francisco 49ers at SoFi Stadium in Inglewood, California, on Sunday, September 17th, with kickoff scheduled for 4:05 p.m. ET. To help you navigate the excitement, we’ve got all the insights and predictions you need with our NFL betting picks tonight.

These fierce NFC West rivals last clashed on October 30th, where the 49ers emerged victorious with a 31-14 win at SoFi Stadium. San Francisco has maintained the upper hand in recent matchups, winning eight of the last nine contests. However, it’s worth noting that the Rams’ last victory over the 49ers was a memorable 20-17 triumph in the NFC Championship game on January 30, 2022.

San Francisco 49ers vs Los Angeles Rams 9/17/2023

When:Sunday, September 17, 2023 ​4:05 PM ET
Where:SoFi Stadium
San Francisco 49ers vs Los Angeles Rams 9/17/2023
49ers-7 (-113)-28542 o (-110)
Rams+7 (-107)+24043 u (-110)
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Kyle Shanahan vs Sean McVay

Los Angeles kicked off the season with an impressive upset against the Seattle Seahawks in Week 1. Despite being 4.5-point underdogs, the Rams turned the tables on Seattle, recovering from a 13-7 halftime deficit to secure a convincing 30-13 win. Even without star receiver Cooper Kupp, quarterback Matthew Stafford shone, completing 24 of 38 passes for an impressive 334 yards.

Stafford found reliable targets in Tutu Atwell and Puka Nacua, both racking up 119 receiving yards. Nacua’s 10 receptions were particularly notable, while Kyren Williams contributed with two rushing touchdowns on 15 carries for 52 yards. Cam Akers added another rushing touchdown, though he managed only 29 yards from 22 carries.

In Week 1, the San Francisco 49ers faced little difficulty against the Pittsburgh Steelers, cruising to a comfortable 30-7 victory. Second-year quarterback Brock Purdy showcased his skills, connecting with receiver Brandon Aiyuk for two touchdown passes in the first half. By halftime, the 49ers led 20-7, and they maintained control throughout the game. Christian McCaffrey’s explosive 65-yard touchdown run in the third quarter and a field goal from Jake Moody in the fourth sealed the deal.

Purdy completed 19 of 29 passes for 220 yards, with eight of those completions finding Aiyuk, who ended the day with an impressive 129 receiving yards. McCaffrey dominated on the ground, rushing 22 times for an outstanding 152 yards, and he also contributed in the passing game with three receptions for 17 yards.

NFL Latest Odds: SF -7.5 ; O/U 44

Despite both teams starting the season with a win, the San Francisco 49ers possess a considerably stronger defense compared to the Los Angeles Rams. While the Rams’ offense showed promise in their Week 1 victory, it’s worth noting that they were aided by Seattle losing both starting offensive tackles during the game. Any doubts about Brock Purdy’s ability to lead the 49ers’ offense were largely dispelled in their convincing win.

San Francisco 49ers vs Los Angeles Rams Betting Numbers


San Francisco 49ers Betting Trends

San Francisco is 10-2 ATS in their last 12 games.
49ers is 13-1 SU in their last 14 games.
San Francisco is 7-0 ATS in their last 7 games against LA Rams.
San Francisco is 8-1 SU in their last 9 games against LA Rams.
49ers is 5-1 SU in their last 6 games on the road.
San Francisco are 5-0 ATS in their last 5 games when playing on the road against LA Rams.

LA Rams Betting Trends

LA Rams are 5-2 ATS in their last 7 games.
The total has gone UNDER in 4 of the LA Rams’ last 6 games.
LA Rams are 3-9 SU in their last 12 games.
The total has gone UNDER in 5 of the LA Rams’ last 7 games against San Francisco.
The total has gone OVER in 4 of the LA Rams’ last 5 games at home.
LA Rams are 0-5 ATS in their last 5 games when playing at home against San Francisco.

San Francisco 49ers vs Los Angeles Rams Betting Picks

The 49ers boast a formidable offensive arsenal, making another victory well within reach. With the likes of Brandon Aiyuk, Deebo Samuel, and George Kittle receiving threats and Christian McCaffrey’s explosive ground game, San Francisco appears poised for success.

In conclusion, the Rams vs. 49ers clash promises to be a high-stakes showdown with playoff implications. While the 49ers have recently dominated this rivalry, the Rams are eager to turn the tide. NFL fans, brace yourselves for an action-packed game at SoFi Stadium as these two NFC West giants go head to head in pursuit of another vital win in Week 2. Take the 49ers to win and cover as per the NFL predictions for this week.

Score Prediction: 49ers 30, Rams 17.