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New York Giants vs San Francisco 49ers 9/21/2023 NFL Picks, Tips and Predictions

New York Giants vs San Francisco 49ers 9/21/2023 – As Week 3 of the NFL season nears “Thursday Night Football” offers us an intriguing matchup between the New York Giants (1-1) and San Francisco 49ers (2-0). Set for kickoff at 8:15 p.m. ET on Thursday, September 21, this clash promises an epic battle between two talented squads. Amazon Prime members across the country will have an opportunity to witness Brock Purdy and Christian McCaffrey of the 49ers go head-to-head with Daniel Jones (if eligible to play) and Saquon Barkley of the Giants in an exciting contest. The NFL Week 3 betting odds are up and running as these teams clash in this important game.

New York Giants vs San Francisco 49ers 9/21/2023

When:Thursday, September 21, 2023 8:15 PM ET
Where:Levi’s Stadium
New York Giants vs San Francisco 49ers 9/21/2023
Giants+9.5 (-112)+30043.5 o (-111)
49ers-9.5 (-110)-45043.5 u (-111)
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Brian Daboll vs Kyle Shanahan

The New York Giants scored their inaugural win of the season with an epic come-from-behind victory against the Arizona Cardinals in Week 2. However, all eyes will now turn toward Saquon Barkley who suffered an ankle injury late in that contest and could determine their success or otherwise in Week 3. Barkley may play an essential role if and when available.

So far in 2017, the San Francisco 49ers have made quite an impressionful statement in the NFL with two impressive victories against the Pittsburgh Steelers and Los Angeles Rams. Brock Purdy wasn’t perfect against the Los Angeles Rams but still displayed impressive efficiency due to their ample collection of offensive weapons at his disposal. It will be interesting to see how Brandon Aiyuk recovers from shoulder surgery over such a short timeframe; either way though, their offense seems poised to score against the New York Giants with relative ease.

Normally, taking double-digit spread points would seem to be the wise decision on short weeks; however, with the Giants’ recent struggles proving arduous for them, taking the points may prove risky, particularly if Barkley is sidelined or restricted from playing.

The New York Giants: NFL Betting Trends, San Francisco Struggles, and Road Success

The New York Giants were an intimidating presence in NFL betting. They covered the spread (ATS) in 12 out of 18 games in recent seasons – an astounding achievement that displayed their ability to defy expectations while keeping things tight on the scoreboard, making them worth keeping an eye on for any savvy bettor.

However, things changed significantly when they met up with the San Francisco 49ers. When competing against this opponent, the Giants struggled remarkably against covering the spread and only managed one time over their last five matchups to record an unimpressive 1-4 record in terms of covering. Many wondered whether San Francisco held some psychological advantage against them.

Once the Giants took to the road, things changed dramatically in their favor. They had proven themselves reliable when playing away from home – posting an 8-3 record against the spread (ATS) over their last 11 away games. Perhaps a change of scene brought out their best performance as they relished taking on unfamiliar ground and outwitting odds-makers with confidence.

New York Giants’ Mixed Fortunes: Success vs. 49ers, Struggles Against NFC Conference and West Division

Giants seem to find success against the 49ers when taking to their own turf and playing against them; their impressive 5-2 against-the-spread record in seven encounters between 2015-17 was a testament to that fact; perhaps something about their style of play complemented Giants’ strengths better?

However, when it came to straight-up (SU) victories against NFC conference opponents, the Giants were in a rough patch. They could only muster a 3-8-1 record in their last 12 games. The competition within their own conference was fierce, and the Giants were struggling to emerge victorious.

Within the NFC West division, which housed the 49ers, the Giants faced even greater challenges. Their record against divisional rivals stood at a daunting 3-10 SU in their last 13 games. It was clear that the NFC West was a formidable battleground, and the Giants were finding it hard to conquer.

NFL Betting Pick San Francisco 49ers -10

Looking at their historical performance, another trend emerged. When the calendar flipped to September, games involving the Giants tended to lean towards the “UNDER” category. The total had gone UNDER in 8 of their last 12 games played in this month. It was a pattern that spoke to a perhaps cautious approach in the early stages of the season.

Turning our attention to the San Francisco 49ers, they were no strangers to impressive ATS records. In their last 13 games, they had secured victory against the spread in 10 instances. It was a testament to their consistency in covering the expectations set by the bookmakers.

New York Giants vs San Francisco 49ers Betting Numbers


New York Giants Betting Trends

NY Giants are 12-6 ATS in their last 18 games.
NY Giants are 1-4 ATS in their last 5 games against San Francisco.
Giants are 8-3 ATS in their last 11 games on the road.
NY Giants are 5-2 ATS in their last 7 games when playing on the road against San Francisco.
NY Giants are 3-8-1 SU in their last 12 games against an opponent in the National Football Conference.
Giants are 3-10 SU in their last 13 games against an opponent in the National Football Conference West division.

San Francisco 49ers Betting Trends

San Francisco is 10-3 ATS in their last 13 games.
49ers is 14-1 SU in their last 15 games.
The total has gone OVER in 4 of San Francisco’s last 5 games against NY Giants.
San Francisco is 7-0 ATS in their last 7 games at home.
San Francisco is 2-5 ATS in their last 7 games when playing at home against NY Giants.
49ers are 10-1 SU in their last 11 games against an opponent in the National Football Conference.

New York Giants vs San Francisco 49ers Betting Picks

When it came to SU victories, the 49ers were nothing short of dominant, having won 14 out of their last 15 games. It was a remarkable streak that showcased their ability to not only meet but exceed expectations when it came to securing outright wins.

In their matchups against the Giants, one thing was evident – points tended to pile up. The total had gone OVER in 4 of their last 5 meetings. When these two teams collided, it often led to high-scoring affairs that thrilled fans and bettors alike. The NFL betting lines are leaning towards the 49ers to secure a victory in this entertaining game.

Score Prediction: 49ers 34, Giants 31.