NFL Week 1 Odds
NFL Week 1 odds open the new season with a full schedule of marquee games. This year’s slate includes a Super Bowl rematch between the Seahawks and Patriots, an NFC East matchup between the Cowboys and Giants, and a Monday night AFC West clash between the Chiefs and Broncos — enough variety to keep bettors and oddsmakers busy for the entire opening week.
NFL Week 1 betting odds cover point spreads, moneylines, and totals for the full league slate, and these numbers move as kickoff gets closer. The table below shows the current NFL odds at BetNow.
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NFL Week 1 Betting Odds and Lines
These openers set the tone for this year’s NFL Week 1 odds. The Seahawks, fresh off raising their second Lombardi Trophy, opened as 3.5-point favorites at home against the Patriots.
Dallas opened on the road as a slight favorite heading into Sunday night vs. the Giants, while Kansas City came in as 2.5-point favorites at home against Denver on Monday. The Ravens started as 3.5-point favorites against the Colts, and Buffalo opened as 1.5-point favorites in their trip to face the Texans. The season kicks off Wednesday, Sept. 9, in Seattle.
None of those numbers are fixed. NFL Week 1 lines shift constantly — an injury report, a strong preseason snap count, or a coaching change can swing a line within hours. Opening spreads, moneyline odds, and totals markets can look very different by game time, so checking close to kickoff usually beats locking in whatever number showed up first.
Some NFL odds tracked early in the week can look very different by Sunday, so checking close to kickoff usually beats locking in whatever number showed up first. BetNow’s board updates with each move, which means what you see reflects the market now, not where it opened back in the early summer.
Popular NFL Week 1 Betting Markets
NFL Week 1 moneyline and spreads draw plenty of attention, but the league’s opening week offers more options. From Las Vegas market makers to online sportsbooks, bettors can decide whether to back a favorite, target a prop, or hold out for live value.
Moneyline
Pick the outright winner with no spread attached. Makes sense for simple exposure to favorites like the Lions or Chargers, or underdog prices in games with the Raiders, Titans, Panthers, or Jaguars.
Point Spread
Bet on the margin of victory, not just the winner. Week 1 spreads draw attention in matchups like Rams vs. 49ers in Australia, Lions vs. Saints, and Cardinals vs. Chargers, with favorites at -2.5, -7, and -11.5.
Totals (Over/Under)
Bet on whether the combined score finishes over or under. Especially popular when explosive offenses like the Bills, Bengals, Eagles, Falcons, Bears, or Packers hit the board.
Player Props
Wager on individual stats such as passing yards, rushing attempts, touchdowns, or receptions. These markets grow once depth charts take shape and preseason usage starts to show role changes.
Same Game Parlays
Combine multiple picks from one matchup into a single ticket. Bettors often mix a side, a total, and player props to build a bigger payout.
Live Betting
Bet after kickoff as odds update in real time. Makes sense once the action has begun, especially when early drives, injuries, or momentum shifts hit the number.
NFL Week 1 totals appeal to those chasing a specific player, game script, or scoring angle, while new bettors usually start with spreads and moneylines.
Why NFL Week 1 Is Popular for Bettors
Nothing else on the calendar works quite like the start of the championship. Every other week, bettors have weeks of tape to reference. Here, there’s none — just offseason roster moves and a handful of preseason snaps to go on, and that uncertainty is exactly why so many people pay attention.
Books set their first NFL opening week odds based on what changed since last season: free agency, the draft, a new coordinator, an injury that lingered into camp. A team that fell apart down the stretch the year before might open as a live underdog if the right pieces got added. A reigning contender, on the other hand, can land a tighter number than expected if its roster turned over more than fans realized.
This year’s matchup card adds to the draw for NFL opening weekend betting on its own. A Super Bowl rematch in Seattle, an NFC East rivalry renewed in the Meadowlands, an AFC West tilt under Monday night lights, and the league’s first regular-season trip to Melbourne for the 49ers and Rams — Week 1 covers a wide range of storylines and price points, from heavy chalk to coin-flip lines bettors will be arguing about all week.
NFL Week 1 Live Betting
Once the ball is kicked off, the pre-game number stops mattering as much. NFL Week 1 odds shift with the game itself — a turnover, a long drive, or an injury on either sideline can move the line within minutes.
First-half betting is another common live option, resetting the board after the opening 30 minutes instead of the original projection.
Player props follow the same logic during the game, adjusting as a quarterback’s workload or a receiver’s target share becomes clear in real time.
Week 1 makes this especially useful, since early-season numbers are built on limited information and sportsbooks adjust quickly once the action starts.
Why Bet NFL Week 1 Odds at BetNow
BetNow carries a full board of NFL season opener odds, with NFL Week 1 odds updating as the market moves throughout the week. Thursday, Monday, or Sunday match, here is what you get here:
Competitive Odds
Competitive odds on spreads, moneylines, and totals
Live Betting
Live betting across the entire Week 1 schedule
Mobile Sportsbook
A mobile sportsbook that works from a phone, no separate app required
Wide Betting Markets
Wide betting markets, including props and same-game parlays
One Board for the Week
One board for the whole week instead of hunting through separate game pages
Bettors following the league’s marquee windows can check the NFL prime time games page for a closer look at the Sunday and Monday matchups specifically.
FAQ
What are NFL Week 1 odds?
These are NFL betting lines sportsbooks set for each opening-week matchup — point spread, moneyline, and total — for every game on the schedule.
When are NFL Week 1 betting lines released?
Early numbers are usually posted in the offseason. Then, they are adjusting through camp, preseason action, and the run-up to kickoff.
What betting markets are available for Week 1?
NFL Week 1 games cover it all: moneylines, point spreads, totals, player props, same game parlays, and live in-play betting.
Can you bet on NFL Week 1 player props?
Yes, props let you wager on individual performances like passing yards or touchdowns, separate from who wins the game.
Is live betting available during Week 1 games?
Yes. Odds update with each game, so bets can go down during the course of the game.
How do NFL Week 1 spreads work?
The spread sets a margin a favorite has to clear (or an underdog has to stay within), regardless of which team is favored going in.