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San Francisco 49ers vs. Los Angeles Chargers NFL Football Betting Picks

Posted by: Anthony Yaylor
San Francisco 49ers vs. Los Angeles Chargers NFL Betting Picks

San Fran had big hopes for the 2018 NFL football betting season. After Jimmy Garoppolo lead them to a 5-0 finish to close out last year’s action, the Niners felt like they had found their new face of the franchise. Unfortunately, the Garoppolo-led Niners faltered to 1-2 in their first three games of the season. What’s worse is that Jimmy G is now out for the season after suffering an ACL tear. Now, without their once-hailed savior, the 49ers have to scrap what’s left of the 2018 NFL season. What type of sportsbook odds are they facing on the road in this weekend’s San Francisco 49ers vs. Los Angeles Chargers matchup?

San Francisco 49ers vs. Los Angeles Chargers – Sunday, September 30th             

When: 4:25 pm ET

Where: StubHub center, Carson, California


Stream: CBS Sports, NFL Game Pass

NFL Football Betting Odds:

San Francisco 49ers +10½ (-115)     46 (-110)         +371

Los Angeles Chargers -10½ (-105)   46 (-110)         -480

San Francisco 49ers 

Coming off a 38-27 road loss to the Chiefs, the 49ers could really use a win this weekend in order to avoid losing too much morale. With Garoppolo now out for the year, CJ Beathard steps in to fill the starting role. Beathard was drafted by the Niners in the 3rd round of the 2017 draft. Last season Beathard played in 7 games and was able to rack up a total 1,430 passing yards, 4 TD, but a whopping 6 INT. All in all he finished his rookie year with a lackluster 69.2 passer rating. Those numbers don’t give San Fran a lot of hope for this upcoming weekend’s matchup. However, Beathard and the 49ers can turn to Matt Breida and their running game for some support. The Niners’ running game has been formidable this season, seeing as they’re racking up 152.7 rushing yards per game. However, Breida is nursing some injuries and might not be at 100% this Sunday. Ultimately, no matter who is in the backfield, San Fran should be able to enjoy success on the ground against Los Angeles. This is because LA gives up a whopping 120.3 rushing yards per game.

Players to Watch: Jimmy Garoppolo (718 passing yards, 5 TD, 3 INT), Matt Breida (274 rushing yards, 1 TD, 0 F), and George Kittle (191 receiving yards, 0 TD, 12 REC).

Los Angeles Chargers

The Chargers charge into this inter-conference pairing flashing a 1-2 record that pegs them as the 3rd worst team in the AFC West. The Chiefs have emerged as the leaders of the division after posting a flawless 3-0 record to kick off the season. Clearly LA needs a win this Sunday to avoid falling too far behind Kansas City, especially when considering how dominant the Chiefs have looked so far. The NFL football betting odds seem to think there’s no way Los Angeles loses this matchup, and it’s looking like that will be the case. While San Fran should enjoy plenty of success on the ground, the Chargers can eliminate that threat by jumping to an early lead. Considering that San Francisco has a -2 turnover ratio this season, and considering they give up a whopping 301.7 passing yards and 29.7 points per game, it shouldn’t be too hard for the Chargers to get that early lead.

Players to Watch: Philip Rivers (906 passing yards, 8 TD, 1 INT), Melvin Gordon (172 rushing yards, 2 TD, 0 F), and Keenan Allen (219 receiving yards, 1 TD, 17 REC).

San Francisco 49ers vs. Los Angeles Chargers Betting Predictions


  • The TOTAL has gone OVER in 7 of San Francisco’s last 10 games when playing LA Chargers
  • San Francisco is 1-4 SU in its last 5 games when playing LA Chargers
  • San Francisco is 1-5 ATS in its last 6 games when playing LA Chargers
  • The TOTAL has gone UNDER in 4 of LA Chargers’ last 6 games at home
  • LA Chargers is 5-1 SU in its last 6 games at home
  • LA Chargers is 4-9 ATS in its last 13 games at home
San Francisco 49ers vs. Los Angeles Chargers Betting Picks

So which side should cell phone betting fans take in San Francisco 49ers vs. Los Angeles Chargers matchup? All in all Los Angeles is the only way to bet here. Taking them straight up doesn’t offer much value so you’d be better sticking to the spread here. Sign up today to make your online betting prediction!

Score Prediction: 30-17 Los Angeles.