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San Francisco 49ers vs. Kansas City Chiefs NFL Game Betting Preview

Posted by: Charlie Smith
San Francisco 49ers vs. Kansas City Chiefs NFL Betting Odds

When the Kansas City Chiefs decided to make the change to Patrick Mahomes, NFL game betting players were uncertain as to how they would fare. But two weeks into the season, the Chiefs have defied our expectations. Sporting an undefeated record, the franchise is now poised to make a home stand in this Sunday’s San Francisco 49ers vs. Kansas City Chiefs matchup. Considering how well Jimmy Garoppolo & the 49ers rebounded in Week 2, this is without a doubt one of the matchups to wager on this weekend. Let’s check the legal betting odds to see what kind of turnout we can expect.

San Francisco 49ers vs. Kansas City Chiefs – Sunday, September 23rd            

When: 1:00 pm ET

Where: Arrowhead Stadium, Kansas City, Missouri

TV: Fox

Stream: NFL Game Pass, Fox Sports Go

NFL Game Betting Odds:

49ers +6½ (-105) 56½ (-110)   +237
Chiefs -6½ (-115) 56½ (-110) -290
Bet Now on this Game

San Francisco 49ers 

The Niners kicked the season off with a humbling 24-16 loss to the Minnesota Vikings on the road. After being praised for leading this team to a 5-0 finish at the end of 2017, Garoppolo failed to live up to his 2018 expectations. While some felt that his lackluster performance was justified by the fact that Jimmy G was facing the Minnesota Vikings – widely considered one of the top 3 defenses in the NFL. However, others felt that Garoppolo needed a solid outing to justify his worth to the organization. Well Garoppolo delivered just that in his second game of the season, leading San Fran to a crucial 30-27 win over the Lions. Garoppolo asserted himself by delivering a 206 yard, 2 touchdown and 0 interception performance. Granted, the run game helped San Francisco out massively, as they racked up 190 on the day.

Players to Watch: Jimmy Garoppolo (467 passing yards, 3 TD, 3 INT), Matt Breida (184 rushing yards, 1 TD, 0 F), and George Kittle (112 receiving yards, 0 TD, 7 REC).   

Kansas City Chiefs

As aforementioned, the Chiefs are undefeated so far into the season. And while they have looked tremendous, NFL game betting players should take their success with a grain of salt. Over the last couple of years, Andy Reid’s teams have burst out onto the scene. Employing a high-powered, versatile offense, the Chiefs seem unbeatable through the first weeks of the season. But once November and December roll around, the Chiefs are notorious for stuttering out. So, since this is an early season matchup, we can fully expect the Chiefs to come out in full force. The Niners give up a tremendous amount of yards so expect Mahomes to be on fire this weekend.

Players to Watch: Patrick Mahomes (582 passing yards, 10 TD, 0 INT), Kareem Hunt (124 rushing yards, 0 TD, 0 F), and Tyreek Hill (259 receiving yards, 3 TD, 12 REC).

San Francisco 49ers vs. Kansas City Chiefs Betting Predictions


  • The TOTAL has gone UNDER in 4 of San Francisco’s last 5 games on the road
  • San Francisco is 2-5 ATS in its last 7 games when playing Kansas City
  • San Francisco is 1-4 SU in its last 5 games when playing on the road against Kansas City
  • The TOTAL has gone UNDER in 5 of Kansas City’s last 5 games at home
  • Kansas City is 18-6 SU in its last 24 games at home
  • Kansas City is 4-2 ATS in its last 6 games at home
San Francisco 49ers vs. Kansas City Chiefs Betting Picks

So which side should mobile betting fans take in this San Francisco 49ers vs. Kansas City Chiefs matchup? All things considered, the Chiefs are the only way to go here. The Chiefs will be playing at home and have enough momentum to topple San Fran. Sign up today to make your online betting prediction!

Score Prediction: 42-33 Kansas City.