San Francisco 49ers vs. Arizona Cardinals 1/5/25 – As the regular season closes, one more pivotal NFC matchup is on the books: the San Francisco 49ers standing at 6-10 battle for some level of respect against the Arizona Cardinals with a standing record of 7-9. This match is scheduled for Sunday and although both teams have already been eliminated from postseason contention, this match is still a matter of pride as well as a better draft order. The state farm stadium awaits the teams as the fixtures paint a picture of an enthralling contest.
San Francisco 49ers vs. Arizona Cardinals 1/5/25
| When: | Sunday, January 5, 2025, at 4:25 PM ET |
|---|---|
| Where: | State Farm Stadium |
| TV: | FOX |
| Stream: | NFL Game Pass |
| Team | SP/RL | TOTAL | ML | |
|---|---|---|---|---|
| 49ers | -2.5 (-112) | Over 46.5 (-110) | -110 |  |
| Cardinals | +2.5 (-110) | Under 46.5 (-112) | -110 | |
| ||||
Gameday in the desert 🌵#FTTB pic.twitter.com/44FL3P1pSd
— San Francisco 49ers (@49ers) January 5, 2025
The betting odds are very tight with the 49ers slightly preferring to be 2.5 points ahead. The two teams have the same moneyline odds owing to their identical performances over the season and the unknowns surrounding this match-up. Looking at the recent trends from both teams, a point over total might be worth a try for the accumulators.
Brandon Allen QB vs. Kyler Murray QB
Brandon Allen, who replaced the 49ers’ head coach midway through this season, has had an uphill task. Allen has recorded a low success ratio, having only been able to successfully pass the ball 56.7% of the time, which only translates to 199 yards and garnering a 60.3 passer rating over three games. It is how he deals with pressure and manages to make pivotal plays against an inconsistent Cardinals defense that remains his main concern.
On the other hand, regardless of the team’s poor performance, Kyler Murray has managed to perform quite well for Arizona. He has shown that he can change a team’s tide by completing 68.6% of his passes for 3609 throwing yards and making 17 touchdown passes. But Murray has thrown 11 interceptions and has been sacked over 30 times, which is an area that the 49ers might seek to counterattack when the time is right.
Brandon Allen versus Kyler Murray will certainly be interesting since they clash in terms of styles as well as experience. Allen has to remain calm and make the best use of his off encive options against the Cardinals who have been inconsistent with their pass defense. However, one can expect Murray to add pressure on the 49ers’ defense with his dual-threat ability given his strength in the ability to make plays on the fly which could exploit the San Francisco defense’s latest weaknesses.
49ers’ Ground and Air Attack: Recent Struggles Yet Potent Potential
Lately, the 49ers have encountered challenges, losing to Detroit and Miami, which raised issues of vulnerability on defense and inconsistency on offense. The addition of Isaac Guerendo and Jauan Jennings has been a positive development, however. To beat the Cardinals, both Guerendo and Jennings will have to exploit their rushing and receiving abilities, respectively. This will help the team counteract the Cardinals’ home advantage and snatch the victory from them.
Cardinals’ Offensive Dynamics: Building Momentum at Home
James Conner and Marvin Harrison Jr. lead Arizona’s offense, and it has shown some signs of brilliance. A perfect example would be Conner’s rushing yards, which are staggering at 1,094, and Harrison’s receiving yards, which are 822. Yet, as pale as it may sound, their performance in recently losing matches against the Rams and Panthers will have to improve quite literally to efficiently hit at the 49ers’ defense.
Trends
San Francisco 49ers Betting Trends
San Francisco are 1-7 ATS in their last 8 games.
The total has gone OVER in 4 of San Francisco’s last 6 games.
San Francisco are 1-6 SU in their last 7 games.
San Francisco are 4-1 ATS in their last 5 games against Arizona.
San Francisco are 4-1 SU in their last 5 games against Arizona.
Arizona Cardinals Betting Trends
Arizona are 7-3 ATS in their last 10 games.
Arizona are 1-5 SU in their last 6 games.
The total has gone OVER in 5 of Arizona’s last 6 games against San Francisco.
Arizona are 4-1 ATS in their last 5 games at home.
Arizona are 1-4 SU in their last 5 games when playing at home against San Francisco.
San Francisco 49ers vs. Arizona Cardinals Betting Prediction
The match between the 49ers and the Cardinals is anticipated to be a tight contest. Given their head-to-head record against Arizona, the odds slightly favor the 49ers. The best approach in betting would be for the 49ers to cover the spread while the total goes ‘over’ due to the high average total points scored by both teams in their encounters.
Given the kind of season both teams have struggled through consistency is the best way to approach the betting. Prop bets on passing yards of Kyler Murray and rushing yards of Isaac Guerendo are also bound to offer value. For those who are averse to risk and are looking for safer bets this time over the total points seems to be one solid bet based on how these two teams have historically scored against each other.
Score Prediction: 49ers 27, Cardinals 24
Hilbert Mayer
Sports Writer
Hilbert Mayer is a professional sports writer, betting analyst, and content strategist with over 15 years of experience in the sports industry. Before focusing on sports betting analysis and handicapping, Hilbert worked as a sports writer for various news outlets, covering everything from game recaps to in-depth matchup features. Today, he specializes in MLB, NFL, March Madness, and UFC betting, combining his journalistic background with deep statistical expertise and real-world betting insights. His proven track record, sharp reads, and ability to break down complex matchups make him a trusted voice among both casual bettors and seasoned sharps.
Published on: January 5, 2025
Last updated: March 24, 2025