Kansas City Chiefs vs. San Francisco 49ers 10/20/24 – In a fascinating NFL Week 7 clash, the remaining undefeated Kansas City Chiefs (5-0) will face off against the San Francisco 49ers (3-3) at Levi’s Stadium. This game will bring together two teams with an entirely different season opening, but also represents a point of critical importance as they seek to shape their destiny. Set for the 20th of October, 2024, at 4:25 PM ET, the match will be aired live on FOX, making it a hotly contested affair for a lot of people. Here’s what all NFL fans will have to look forward to in one of the most looked-forward-to NFL daily previews.
Kansas City Chiefs vs. San Francisco 49ers 10/20/24
| When: | Sunday, October 20, 2024, at 4:25 PM ET |
|---|---|
| Where: | Levi’s Stadium |
| TV: | FOX |
| Stream: | NFL Game Pass |
| Team | SP/RL | TOTAL | ML | |
|---|---|---|---|---|
| Chiefs | +1.5 (-110) | Over 46.5 (-115) | +100 |  |
| 49ers | -1.5 (-110) | Under 46.5 (-105) | -120 | |
| ||||
Fall football is in the air 😁 pic.twitter.com/67RP3xiAEj
— Kansas City Chiefs (@Chiefs) October 17, 2024
Despite their undefeated status, the Chiefs enter the game as the narrowest of underdogs, which is rather unusual. The point spread also makes the match a highly contested one, with a slight bias towards the home team, the 49ers. The total points line was placed at 46.5, and as per this,s it can be assumed that it is estimated to be an average high-scoring match as both teams have strengths and weaknesses in offense and defense.
Patrick Mahomes QB vs. Brock Purdy QB
This season, many experts in sports betting have been quite lucky with their predictions about Patrick Mahomes. For example, this particular player is still leading the Chiefs with an impressive 69.4%, 1235 yards, and 6 touchdowns under his belt, complete with 6 interceptions for the entire season. While he is known for his game-changing skills during the most important plays, the number of interceptions that he has this season, going into an efficient 49ers defense, will be worrying.
At the same time, Brock Purdy has been a model of efficiency for the 49ers with 1629 yards thrown, 65.4% accuracy, and a 9-4 touchdown to interception figure. Perhaps the most interesting feature of this young quarterback is how he can throw the ball deep, his longest pass being 76 yards, for that matter. This might just test the Chiefs’ corners who have been leaky over the past games.
Dynamic Duos: Kansas City’s Offensive Playmakers
Kareem Hunt and Rashee Rice have been instrumental in the Chiefs’ offensive strategy. Hunt, returning from injury, has quickly reestablished himself, averaging 85.5 rushing yards per game, while Rice has been a reliable target in the air, racking up 288 receiving yards and two touchdowns. Their ability to break free from tackles and gain crucial yards after catch will be key against a 49ers team that struggles with consistency on defense.
San Francisco’s Balanced Offensive Threat
Isaac Guerendo and Jauan Jennings have brought a balanced approach to the 49ers’ offense. Guerendo’s impressive 6.4 yards per rush highlights his explosive potential on relatively few touches, suggesting he could be due for more carries. Meanwhile, Jennings has become Purdy’s favorite receiver, with 404 yards and three touchdowns, providing a reliable option on crucial downs. Their performance will be critical in exploiting the Chiefs’ defensive gaps and maintaining possession.
Trends
Kansas City Chiefs Betting Trends
Kansas City are 9-1-1 ATS in their last 11 games.
The total has gone UNDER in 8 of Kansas City’s last 12 games.
Kansas City are 10-0 SU in their last 10 games.
Kansas City are 7-1 ATS in their last 8 games against San Francisco.
Chiefs are 6-1 SU in their last 7 games against San Francisco.
Kansas City are 6-0 SU in their last 6 games on the road.
San Francisco 49ers Betting Trends
San Francisco are 3-7 ATS in their last 10 games.
The total has gone OVER in 6 of San Francisco’s last 8 games.
San Francisco are 12-6 SU in their last 18 games.
The total has gone OVER in 5 of San Francisco’s last 7 games against Kansas City.
San Francisco are 2-8 ATS in their last 10 games at home.
San Francisco are 5-1 SU in their last 6 games when playing at home against Kansas City.
Kansas City Chiefs vs. San Francisco 49ers Betting Prediction
It would be understandable if Kansas is the preferred team to bet on, given the Chiefs are still looking for their first loss, and the 49ers have not done well at home ATS. Kansas should be able to create an offense that can win them the game, even if most of the revenue is spent on the lead quarterback. This game promises to be close; however, a history of winning games under pressure, especially on the road, should give the Chiefs a slight advantage in this contest.
Looking at both the teams and their performance in the previous matches, the Over on 46.5 points becomes probable. Since both quarterbacks will be mobile and various defensive breakdowns are bound to be exploited, a lot of points will be scored in this particular matchup. Intriguing bets may include specific metrics such as the number of passing yards Mahomes will accomplish or the number of touchdown passes Purdy connects. Remember to always check the relevant lines with the best online sportsbook.
Score Prediction: Kansas City Chiefs 27, San Francisco 49ers 24.
Hilbert Mayer
Sports Writer
Hilbert Mayer is a professional sports writer, betting analyst, and content strategist with over 15 years of experience in the sports industry. Before focusing on sports betting analysis and handicapping, Hilbert worked as a sports writer for various news outlets, covering everything from game recaps to in-depth matchup features. Today, he specializes in MLB, NFL, March Madness, and UFC betting, combining his journalistic background with deep statistical expertise and real-world betting insights. His proven track record, sharp reads, and ability to break down complex matchups make him a trusted voice among both casual bettors and seasoned sharps.
Published on: October 17, 2024
Last updated: March 27, 2025