Arizona Cardinals vs. Buffalo Bills 9/8/24 – With the start of the NFL regular season, the comparison between the Arizona Cardinals and the Buffalo Bills is bound to stand out concerning the opposing stats of the teams. The Cardinals are winless in the preseason (0-3) and will seek an upset against the Bills, who have been better in the preseason at 1-2. Sunday’s early season showdown in Highmark stadium is also an enticing scenario for the supporters and wagers. However, as the teams gear up to lock horns, one thing is also clear the oddsmakers and punters will have a lot of intricacy to analyze in this Week 1 matchup in terms of football betting predictions.
Arizona Cardinals vs. Buffalo Bills 9/8/24
| When: | Sunday, September 8, 2024, at 1:00 PM ET |
|---|---|
| Where: | Highmark Stadium |
| TV: | CBS |
| Stream: | NFL Game Pass |
| Team | SP/RL | TOTAL | ML | |
|---|---|---|---|---|
| Cardinals | +7.5 (-123) | 47.5 over (-103) | +260 |  |
| Bills | -7.5 (+100) | 47.5 under (-119) | -302 | |
| ||||
https://twitter.com/AZCardinals/status/1831046251833614848
The Cardinals, evident underdogs with a +7.5 spread, suggest that they are not just fighting against the Bills, but also against recent poor form. Meanwhile, the Bills, priced heavily at -302 on the moneyline, are expected to dominate. Given these odds, bettors will need to decide if the Cardinals can cover the spread or if the Bills will justify their heavy favoritism by winning big.
Clayton Tune QB vs. Mitchell Trubisky QB
Cardinals quarterback Clayton Tune enters the new campaign with modest numbers in the preseason: 67.3 percent percentage of successful passes, 361 yards, and only one touchdown and one interception recorded. While there is an opportunity for such offensive potential and aggression to develop fully, there is a degree of plausibility that he may not be able to spearhead so much of a recovery against top-notch opposition.
On the flip side, the Bills’ Mitchell Trubisky has also been unproductive, with a completion rate of 61.3% with no touchdown and one interception. His passing yards per attempt stands at lower 5.4, which signifies difficulty in executing passes over 20 yards downfield and this may be a target area against the Cardinals’ defense.
The battle between Tune and Trubisky may not be the most talked about among the many clash, yet it is important. Both QBs have the burden of doing better than in the preseason. This game should hinge on whether Tune can hit targets deep and handle the pressure of the game, or Trubisky will be able to establish a nice rhythm and stay consistent.
Cardinals’ Ground and Air Assault
The Cardinals’ offensive strategy will likely revolve around their rookie running back Trey Benson and receiver Xavier Weaver. Benson, with an average of 3.8 yards per carry, and Weaver, who has shown flashes of brilliance with 95 receiving yards from six receptions, will need to find gaps in the Bills’ defense. Their ability to convert crucial first downs will be instrumental in keeping their drives alive and possibly upsetting the odds.
Bills’ Offensive Playmakers
Frank Gore Jr., with a robust 4.9 yards per carry and a touchdown, is set to be a cornerstone of the Bills’ ground game. His ability to break tackles and convert critical third-down situations will be vital. Meanwhile, tight end Zach Davidson, although not flashy in the preseason, will be an essential target in Trubisky’s short-pass game plan, especially in red zone scenarios.
Trends
Arizona Cardinals Betting Trends
The total has gone OVER in 4 of Arizona’s last 6 games.
Arizona are 4-16 SU in their last 20 games.
Arizona are 1-7 ATS in their last 8 games against Buffalo.
Cardinals are 2-6 SU in their last 8 games against Buffalo.
Arizona are 2-10 SU in their last 12 games on the road.
Buffalo Bills Betting Trends
Buffalo are 5-10 ATS in their last 15 games.
The total has gone OVER in 4 of Buffalo’s last 5 games.
Buffalo are 6-1 SU in their last 7 games.
The total has gone OVER in 6 of Buffalo’s last 7 games against Arizona.
Buffalo are 4-1 SU in their last 5 games at home.
Arizona Cardinals vs. Buffalo Bills Betting Prediction
Considering the detailed assessment and the latest developments, it is fair to recommend the risks with the Bills, which are likely to win the game but not cover the spread as they often do in the ATS statistics. Ontario sports bettors may want to shop around for better angles in the total points market, targeting specifically the OVER with both teams having the ability and willingness to engage in shootouts.
It is important to note that making a wager on a straight win on any of the above teams is not only about the fact that the Bills are playing at home but also the current woes of the Cardinals. The rushing yards prop on Frank Gore Jr. may be worth a few bucks for those interested in looking at the prop bets and the alternative markets. This intriguing and far from monotonous event will bring positive emotions to the participants and the chance to earn for those not new to the premier online casino and sportsbook betting.
Score Prediction: Bills 30, Cardinals 24.
Hilbert Mayer
Sports Writer
Hilbert Mayer is a professional sports writer, betting analyst, and content strategist with over 15 years of experience in the sports industry. Before focusing on sports betting analysis and handicapping, Hilbert worked as a sports writer for various news outlets, covering everything from game recaps to in-depth matchup features. Today, he specializes in MLB, NFL, March Madness, and UFC betting, combining his journalistic background with deep statistical expertise and real-world betting insights. His proven track record, sharp reads, and ability to break down complex matchups make him a trusted voice among both casual bettors and seasoned sharps.
Published on: September 3, 2024
Last updated: March 25, 2025